4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester → 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester

HRID 457829

Reaktionsgleichung

Reaktionsgleichung von HRID 457829
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[NH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].CS(O[CH2:27][CH2:28][C:29]1[CH:33]=[CH:32][S:31][CH:30]=1)(=O)=O>>[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[C:20]3[C:15](=[CH:16][C:17]([F:21])=[CH:18][CH:19]=3)[N:14]([CH2:27][CH2:28][C:29]3[CH:33]=[CH:32][S:31][CH:30]=3)[CH:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 113237384-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl esterHCID 144229343-Thiopheneethanol methanesulfonate

Produkt 1

HCID 694123954-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl esterAusbeute 101,3 %

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 3.3 g (16 mmol) of 2-thiophen-3-yl-ethyl methansulfonate. The reaction mixture was stirred at 60° C. for 3 hours. After standard work-up, 5.6 g (100% of yield) of 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.

Aufarbeitung

  1. customThis compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-de6761be560c4262a651feeb08deebc2
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189741B2

Verknüpfte Notizen

Wird geladen…