HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
O-((4-Methoxyphenyl)methyl)hydroxylamine → Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | O-((4-Methoxyphenyl)methyl)hydroxylamine | HCID 120426 | — |
| Edukt | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | HCID 11593804 | — |
| Edukt | tert-butoxycarbonyl-4-(methoxyimino)-2-Pyrrolidinecarboxylic acid | HCID 72828956 | — |
| Produkt | Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid | HCID 73876899 | 85% |
Reaktionsschritte
The same method as employed in the preparation of Intermediate 7, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1[(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07189754B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-235e92cbb3e34fcf9cf44aa06c42ac6b |
| Quellennotiz | uspto-grants-2007_03 |