O-((4-Methoxyphenyl)methyl)hydroxylamine → Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid

HRID 457912

Reaktionsgleichung

Reaktionsgleichung von HRID 457912
[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH3:15])[CH2:10][CH:9]1[C:16]([OH:18])=[O:17])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(N1CC(=O)C[C@H]1C(O)=O)=O)(C)(C)C.NOC[C:38]1[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][C:11](=[N:13][O:14][CH2:15][C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=2)[CH2:10][CH:9]1[C:16]([OH:18])=[O:17])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

4

Edukt 3

HCID 120426O-((4-Methoxyphenyl)methyl)hydroxylamine2×HCID 11593804(2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid2×HCID 72828956tert-butoxycarbonyl-4-(methoxyimino)-2-Pyrrolidinecarboxylic acid

Produkt 1

HCID 73876899Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acidAusbeute 85 %

Versuchsvorschrift

The same method as employed in the preparation of Intermediate 7, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1[(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield.

Quellen und Nachweise

ORD-Eintrag
ord-235e92cbb3e34fcf9cf44aa06c42ac6b
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189754B2

Verknüpfte Notizen

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