Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

HRID 458159

Reaktionsgleichung

Reaktionsgleichung von HRID 458159
[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH2:4].C(=O)([O-])[O-].[K+].[K+].CS(O[C@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24])(=O)=O>[Cl-].C([N+](CCCCCC)(CCCCCC)CCCCCC)CCCCC>[F:1][C:2]1[C:8]([F:9])=[C:7]([F:10])[CH:6]=[CH:5][C:3]=1[NH:4][C@@H:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 774682,3,4-TrifluoroanilineHCID 57320743Methyl (2R)-2-[(methylsulfonyl)oxy]propanoate

Produkt 1

HCID 10125210Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80021Tetrahexylammonium chlorideKatalysator

Versuchsvorschrift

In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.

Aufarbeitung

  1. customIn accordance with the process of Example 2, a condensation reaction

Quellen und Nachweise

ORD-Eintrag
ord-e2e360e1f059450f842dbf691f52e7f1
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189847B2

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