Hydrochloric Acid → (2S)-2-(2,3,4-trifluoroanilino)propionic acid

HRID 458175

Reaktionsgleichung

Reaktionsgleichung von HRID 458175
[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7].C1([C@@H](N)C)C=CC=CC=1.Cl>>[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 67369703HCID 67369703, Verbindung

Produkt 1

HCID 67366567(2S)-2-(2,3,4-trifluoroanilino)propionic acidAusbeute 96 %

Versuchsvorschrift

To (2S)-2-(2,3,4-trifluoroanilino)propionic acid•(S)-1-phenylethylamine salt (1.0 g; 99% ee) were added IPE (20 ml) and hydrochloric acid (1 mol/l) until the pH value reached 1 and the resultant mixture was stirred at room temperature for 1 hour. The organic layer was dried over anhydrous magnesium sulfate. After evaporating the solvent, 618 mg of the title compound was obtained as colorless crystals. The optical purity of this product was 99% ee. The 1H-NMR and IR spectral data of this product was identical with those of the compound obtained in Example 23.

Aufarbeitung

  1. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  2. customAfter evaporating the solvent

Quellen und Nachweise

ORD-Eintrag
ord-13c76af55b6d416fb24bc04ff8a3e530
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189847B2

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