Hydrochloric Acid → 4-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

HRID 458245Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 458245
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:15]O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14].[ClH:17]>O1CCOCC1>[Cl:17][CH2:15][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 18442092(3-Methoxy-4-pent-2-ynyloxy-phenyl)-methanol

Produkt 1

HCID 184420934-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of (3-methoxy-4-pent-2-ynyloxy-phenyl)-methanol (27 g, 0.12 mol) in 450 ml of dioxan is added dropwise to 240 ml of concentrated hydrochloric acid. The reaction mixture is stirred for 1.5 hours at room temperature. Subsequently it is poured on water and extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate and evaporated in vacuo to obtain 4-chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene as yellow oil.

Aufarbeitung

  1. additionSubsequently it is poured on water
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layer is washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7a630b6eee2b467e860d1d0089b0a612
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189873B2

Notizen zur Reaktion

Wird geladen…