4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol

HRID 458266Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 458266
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[F:12][C:13]1[C:20]([F:21])=[C:19]([C:22]([F:25])([F:24])[F:23])[C:18]([F:26])=[C:17]([F:27])[C:14]=1[CH2:15]Br>CN(C=O)C>[N+:9]([C:4]1[CH:3]=[C:2]([NH:1][CH2:15][C:14]2[C:17]([F:27])=[C:18]([F:26])[C:19]([C:22]([F:23])([F:25])[F:24])=[C:20]([F:21])[C:13]=2[F:12])[CH:7]=[CH:6][C:5]=1[OH:8])([O-:11])=[O:10]

Komponenten

4

Edukt 2

HCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromideHCID 34174194-Amino-2-Nitrophenol

Produkt 1

HCID 104300752-Nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenolAusbeute 40,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

According to the similar procedure in Synthesis Example 1, by using 4-amino-2-nitrophenol (1.00 g, 6.49 mmole), DMF (30 ml), TEA (0.5 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.30 g, 7.78 mmole), 1.00 g (40.0% yield) of 2-nitro-4-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)phenol was obtained as a reddish solid.:

Aufarbeitung

  1. customAccording to the similar procedure in Synthesis Example 1

Quellen und Nachweise

ORD-Eintrag
ord-b4f18ef82045480aab03664baa1ff483
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189878B2

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