HCID 178505869, Verbindung → HCID 178507659, Verbindung

HRID 45844

Reaktionsgleichung

Reaktionsgleichung von HRID 45844
C([N:8](CC1C=CC=CC=1)[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[C:11]([C:16]2[C:20]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[CH:19][NH:18][N:17]=2)[C:10]=1[F:27])C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[F:27][C:10]1[C:11]([C:16]2[C:20]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[CH:19][NH:18][N:17]=2)=[C:12]([F:15])[CH:13]=[CH:14][C:9]=1[NH2:8]

Komponenten

4

Edukt 1

HCID 178505869HCID 178505869, Verbindung

Produkt 1

HCID 178507659HCID 178507659, VerbindungAusbeute 56 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To dibenzyl-[2,4-difluoro-3-(4-pyridin-4-yl-1H-pyrazol-3-yl)-phenyl]-amine (1.795 g, 3.97 mmol) in methanol (100 mL) was added 20% palladium hydroxide on carbon (646 mg). The reaction was stirred under hydrogen atmosphere for 12 hours (45 psi). The reaction was filtered to remove the catalyst, and then concentrated under reduced pressure. The crude was purified by silica gel column chromatography eluting with methanol 7% in methylene chloride to give 2,4-difluoro-3-(4-pyridin-4-yl-1H-pyrazol-3-yl)-phenylamine (yield 56% over three steps).

Aufarbeitung

  1. filtrationThe reaction was filtered
  2. customto remove the catalyst
  3. concentrationconcentrated under reduced pressure
  4. customThe crude was purified by silica gel column chromatography
  5. washeluting with methanol 7% in methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-a9ae1a1bae8e4319b2e90a64f21b9ba1
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541575B2

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