1-(Bromomethyl)-2-(trifluoromethyl)benzene → 8-Bromo-3-methyl-7-(2-trifluoromethylbenzyl)-3,7-dihydropurine-2,6-dione

HRID 458638Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 458638
[Br:1][C:2]1[NH:10][C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1.[F:14][C:15]([F:25])([F:24])[C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Br>>[Br:1][C:2]1[N:10]([CH2:18][C:17]2[CH:20]=[CH:21][CH:22]=[CH:23][C:16]=2[C:15]([F:14])([F:24])[F:25])[C:9]2[C:8](=[O:11])[NH:7][C:6](=[O:12])[N:5]([CH3:13])[C:4]=2[N:3]=1

Komponenten

3

Edukt 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 15487978-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione

Produkt 1

HCID 225086498-Bromo-3-methyl-7-(2-trifluoromethylbenzyl)-3,7-dihydropurine-2,6-dioneAusbeute 69 %

Versuchsvorschrift

8-Bromo-3-methyl-3,7-dihydropurine-2,6-dione and 2-(trifluoromethyl)benzyl bromide were reacted and purified as described in the General procedure G, step A, to afford 81A as white crystals in 69% yield.

Aufarbeitung

  1. custompurified

Quellen und Nachweise

ORD-Eintrag
ord-ec64551aff234d2b9aef59de7a6d6f97
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192952B2

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