6-Hydroxyflavone → (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-6-yloxy)-prop-1-ynyl]-phenyl}-propionic acid

HRID 459083

Reaktionsgleichung

Reaktionsgleichung von HRID 459083
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[OH:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[O:27][C:26]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[CH:25][C:24]2=[O:37]>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][O:20][C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[O:27][C:26]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:25][C:24]3=[O:37])=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

Komponenten

3

Edukt 2

HCID 722796-HydroxyflavoneHCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

Produkt 1

HCID 10162589(2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-6-yloxy)-prop-1-ynyl]-phenyl}-propionic acid

Versuchsvorschrift

The title compound was prepared from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5, Step A and 6-hydroxyflavone in a manner analogous to that described for Example 5, Step B. MS(ES) for C28H22O6[M+H]+: 455.2.

Quellen und Nachweise

ORD-Eintrag
ord-14c15e9a1a824275a15158ac990aae9c
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

Verknüpfte Notizen

Wird geladen…