4-Cyclopentylphenol → (2S)-3-{4-[3-(4-Cyclopentyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid

HRID 459125

Reaktionsgleichung

Reaktionsgleichung von HRID 459125
[OH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1.[CH:19]1([C:24]2[CH:29]=[CH:28][C:27](O)=[CH:26][CH:25]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1>>[CH:19]1([C:24]2[CH:25]=[CH:26][C:27]([O:1][CH2:2][CH2:3][CH2:4][O:5][C:6]3[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=3)=[CH:28][CH:29]=2)[CH2:20][CH2:21][CH2:22][CH2:23]1

Komponenten

3

Edukt 2

HCID 152024-CyclopentylphenolHCID 69424952(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid

Produkt 1

HCID 58822587(2S)-3-{4-[3-(4-Cyclopentyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid

Versuchsvorschrift

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 4-cyclopentylphenol and cleavage from the resin (Standard Procedure G) gave an oily solid.

Aufarbeitung

  1. customgave an oily solid

Quellen und Nachweise

ORD-Eintrag
ord-0fd99128642746fa9ef53d89a733600b
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

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