4-(Trifluoromethyl)phenol → (2S)-2-Methoxy-3-{4-[3-(4-trifluoromethyl-phenoxy)-propoxy]-phenyl}-propionic acid
Reaktionsgleichung
[OH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1.[F:19][C:20]([F:29])([F:28])[C:21]1[CH:26]=[CH:25][C:24](O)=[CH:23][CH:22]=1>>[CH3:18][O:17][C@@H:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:1][C:24]2[CH:25]=[CH:26][C:21]([C:20]([F:29])([F:28])[F:19])=[CH:22][CH:23]=2)=[CH:7][CH:8]=1)[C:14]([OH:16])=[O:15]Komponenten
3
Versuchsvorschrift
The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 4-trifluoromethylphenol and cleavage from the resin (Standard Procedure G) gave an oily solid.
Aufarbeitung
- customgave an oily solid