Guaiacol → 2-Methoxy-3-{3-[3-(2-methoxy-phenoxy)-propoxy]-phenyl}-propionic acid

HRID 459351Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 459351
C[O:2][C:3](=[O:19])[CH:4]([O:17][CH3:18])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][CH2:15]Br)[CH:7]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[OH:28].CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:18][O:17][CH:4]([CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][CH2:15][O:28][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[O:21][CH3:20])[CH:7]=1)[C:3]([OH:2])=[O:19]

Komponenten

4

Edukt 3

HCID 460GuaiacolHCID 588228613-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

Produkt 1

HCID 184432612-Methoxy-3-{3-[3-(2-methoxy-phenoxy)-propoxy]-phenyl}-propionic acid

Versuchsvorschrift

The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-methoxyphenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C20H24O6 [M+Na]+: 383.4.

Aufarbeitung

  1. customThe enatiomers were separated by chiral HPLC

Quellen und Nachweise

ORD-Eintrag
ord-3ac079bc36bb476990ffe619651c691f
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

Notizen zur Reaktion

Wird geladen…