2-Isopropylphenol → 3-{3-[3-(2-Isopropyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid

HRID 459352Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 459352
C[O:2][C:3](=[O:19])[CH:4]([O:17][CH3:18])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][CH2:15]Br)[CH:7]=1.[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29])([CH3:22])[CH3:21].CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH2:15][CH2:14][CH2:13][O:12][C:8]1[CH:7]=[C:6]([CH2:5][CH:4]([O:17][CH3:18])[C:3]([OH:2])=[O:19])[CH:11]=[CH:10][CH:9]=1)([CH3:22])[CH3:21]

Komponenten

4

Edukt 3

HCID 69432-IsopropylphenolHCID 588228613-[3-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

Produkt 1

HCID 184435953-{3-[3-(2-Isopropyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid

Versuchsvorschrift

The title compound was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-isopropylphenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C22H28O5 [M+Na]+: 395.4.

Aufarbeitung

  1. customThe enatiomers were separated by chiral HPLC

Quellen und Nachweise

ORD-Eintrag
ord-846b6e6448b94faca4b20da3beefaf6a
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

Notizen zur Reaktion

Wird geladen…