HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluorophenol → 3-{3-[2-(3-Fluoro-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluorophenol | HCID 9743 | — |
| Edukt | (2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid | HCID 58822897 | — |
| Edukt | 3-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester | HCID 69423413 | — |
| Produkt | 3-{3-[2-(3-Fluoro-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid | HCID 18443589 | — |
Reaktionsschritte
The title compound was prepared from 3-fluoro-phenol and 3-[3-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 351, Step 1) via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C18H19FO5 [M−H]−: 333.1.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07192982B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-33298014baf84261bd8295c3660907ca |
| Quellennotiz | uspto-grants-2007_03 |