Methyl 3-[4-(benzyloxy)phenyl]propanoate → 3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester

HRID 459395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 459395
[CH2:1]([O:3][C:4](=[O:24])[C:5]([O:21][CH2:22][CH3:23])=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)C.COC(=O)C(OC)CC1C=CC=C(OCC2C=CC=CC=2)C=1.COC(=O)CCC1C=CC(OCC2C=CC=CC=2)=CC=1>>[CH3:1][O:3][C:4](=[O:24])[CH:5]([O:21][CH2:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1

Komponenten

4

Edukt 3

HCID 525519Methyl 3-[4-(benzyloxy)phenyl]propanoateHCID 54423854Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoateHCID 588226203-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester

Produkt 1

HCID 219309623-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl esterAusbeute 47,1 %

Versuchsvorschrift

The title compound was prepared from 3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester (Example 375, Step 2) (3.3 gr, 10.12 mmol) via the same procedure used for the preparation of 3-(3-benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 3) to produce an oil that was purified by chromatography (silica gel, hexanes/ethyl acetate 6:1) to produce two compounds: 3-(4-benzyloxy-phenyl)-propionic acid methyl ester (1.5 gr, Rf aprox. 0.65) and the desired compound (1.5 gr, Rf aprox. 0.2).

Aufarbeitung

  1. customto produce an oil that
  2. customwas purified by chromatography (silica gel, hexanes/ethyl acetate 6:1)
  3. customto produce two compounds

Quellen und Nachweise

ORD-Eintrag
ord-cbb72b231ebd4783aca63fbfbd482710
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

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