Ammonium Chloride → Ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate
Reaktionsgleichung
[O:1]1[C@H:7]2[C@@H:2]1[CH2:3][C@@H:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:5][CH2:6]2.[Cl-].[NH4+].[N-:15]=[N+:16]=[N-:17].[Na+]>CN(C)C=O>[N:15]([C@H:2]1[C@H:7]([OH:1])[CH2:6][CH2:5][C@H:4]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:3]1)=[N+:16]=[N-:17]Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 75 °C
Versuchsvorschrift
Ethyl (1S,3S,4R)-3,4-epoxycyclohexane-1-carboxylate (41 g) was dissolved in N,N-dimethylformamide (300 ml), ammonium chloride (19.3 g) and sodium azide (23.5 g) were successively added at room temperature, and the mixture was then stirred at 75° C. for 13 hours. The reaction mixture was filtered, the filtrate was concentrated to distill off 400 ml of the solvent, the product captured by the filter was put in the residue, and water was added to dissolve the collected product. The solution was extracted with ethyl acetate. The resultant organic layer was washed with water and saturated saline and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (51.5 g) as an oil.
Aufarbeitung
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- distillationto distill off 400 ml of the solvent
- additionwas added
- dissolutionto dissolve the collected product
- extractionThe solution was extracted with ethyl acetate
- washThe resultant organic layer was washed with water and saturated saline
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-7adf52f01f5c4521a2cf6cbd6dae2f53
- Quelldatensatz
- uspto-grants-2007_03
- Patentnummer
- US07192968B2
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