Sodium Sulfite → 4-(4-Methoxycarbonylphenyl)pyridine N-oxide

HRID 459543Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 459543
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13][CH3:14])=[O:12])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:25])C=1.S([O-])([O-])=O.[Na+].[Na+]>ClCCl>[CH3:14][O:13][C:11]([C:10]1[CH:15]=[CH:16][C:7]([C:4]2[CH:5]=[CH:6][N+:1]([O-:25])=[CH:2][CH:3]=2)=[CH:8][CH:9]=1)=[O:12]

Komponenten

5

Edukt 3

HCID 24437Sodium SulfiteHCID 70297m-Chloroperbenzoic acidHCID 5152686Methyl 4-(4-pyridinyl)benzoate

Produkt 1

HCID 186176494-(4-Methoxycarbonylphenyl)pyridine N-oxideAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Methyl 4-(4-pyridyl)benzoate (1.49 g) was dissolved in dichloromethane (30 ml), 70% m-chloroperbenzoic acid (3.46 g) was added, and the mixture was stirred at room temperature for 1 hour. An aqueous solution of sodium sulfite was added to conduct liquid separation. The resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the title compound (1.33 g) as white powder.

Aufarbeitung

  1. customliquid separation
  2. washThe resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-68df5064f26c4397add692bd11fca849
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192968B2

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