HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cortisol → Hydrocortisone 4-bromobutanoate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cortisol | HCID 5754 | — |
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-Bromobutyryl chloride | HCID 70225 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | Hydrocortisone 4-bromobutanoate | HCID 86606384 | — |
Reaktionsschritte
Five portions of 4-bromobutanoylchloride (0.35 ml×5) and potassium carbonate (0.4 g×5) were added in 24 hours to a solution of hydrocortisone (1 g) in CHCl3 dried over P2O5 and stirred for 5 days. The solution was treated with water, the organic phase was separated, dried (Na2SO4) and deprived of the solvent at reduced pressure.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07196075B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-d0c3a898023d4f18bfe38e1d231c63a5 |
| Quellennotiz | uspto-grants-2007_03 |