p-Fluoronitrobenzene → (2S,5R)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine
Reaktionsgleichung
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][NH:13]1>CN1C(=O)CCC1>[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][N:13]1[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
An NMP solution of fluoro-4-nitrobenzene and (±)-trans-2,5-dimethylpiperazine was stirred at an oil bath temperature of 120° C. for 3 hours to obtain (±)-trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine, which was further treated in a similar manner to Example 4 to obtain an objective compound.
Quellen und Nachweise
- ORD-Eintrag
- ord-eefa40e2896a40478a7d6d15383254f5
- Quelldatensatz
- uspto-grants-2007_03
- Patentnummer
- US07196080B2
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