2-Methylbenzenesulfonamide → N-[4-(biphenyl-4-ylaminomethyl)-5-methyl-furan-2-carbonyl]-2-methyl-benzenesulphonamide
Reaktionsgleichung
[C:1]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][C:4]([NH:7][CH2:8][C:9]2[CH:10]=[C:11]([C:15]([OH:17])=O)[O:12][C:13]=2[CH3:14])=[CH:3][CH:2]=1.[CH3:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[S:31]([NH2:34])(=[O:33])=[O:32]>>[C:1]1([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:6]=[CH:5][C:4]([NH:7][CH2:8][C:9]2[CH:10]=[C:11]([C:15]([NH:34][S:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH3:24])(=[O:32])=[O:33])=[O:17])[O:12][C:13]=2[CH3:14])=[CH:3][CH:2]=1Komponenten
3
Versuchsvorschrift
Compound (162) was prepared from compound (160) and 2-methyl-benzenesulphonamide by adapting the procedure of Example 38(f). LC/MS System D; Rt=10.39 mins, m/z (ES+)=461 (M+H for C26H24N2O4S).
Quellen und Nachweise
- ORD-Eintrag
- ord-09481b9dec564d2f897db4661a1c54f7
- Quelldatensatz
- uspto-grants-2007_03