1-(Quinolin-4-yl)ethanol → 1-(Quinolin-4-yl)ethan-1-one

HRID 460143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 460143
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:13])[CH3:12])=[CH:3][CH:2]=1>ClCCl.[O-2].[Mn+2]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:13])[CH3:12])=[CH:3][CH:2]=1

Komponenten

4

Edukt 1

HCID 53147551-(Quinolin-4-yl)ethanol

Produkt 1

HCID 123401901-(Quinolin-4-yl)ethan-1-oneAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 160959Manganese oxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin-4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol).

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for overnight
  2. filtrationThe solid was filtered out through Celite pad
  3. dry with materialThe organic solution dried over anhydrous magnesium sulfate
  4. concentrationconcentrated via vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7cac8f31b4584785b737b061818ea1a0
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196102B2

Notizen zur Reaktion

Wird geladen…