HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium cyanoborohydride → (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamine | HCID 20803224 | — |
| Edukt | 6,4'-Dimethoxybiphenyl-3-carbaldehyde | HCID 22391191 | — |
| Edukt | (6,4'-Dimethoxybiphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine | HCID 22391337 | — |
| Produkt | (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amine | HCID 22391549 | 55% |
Reaktionsschritte
The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamine (528 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 55% yield (221 mg, 5.5 mmol).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07196102B2 |
| Quelldatensatz | uspto-grants-2007_03 |
| ORD ID | ord-ee4f5d0fe81d446299a0c40ff00d171c |
| Quellennotiz | uspto-grants-2007_03 |