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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 460154Erstellt: 25. Oktober 2026

Sodium cyanoborohydride → (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amine

https://huagongshe.com/reaction/460154

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktSodium cyanoborohydrideHCID 5003444—
Edukt1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamineHCID 20803224—
Edukt6,4'-Dimethoxybiphenyl-3-carbaldehydeHCID 22391191—
Edukt(6,4'-Dimethoxybiphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amineHCID 22391337—
Produkt(6,4'-Dimethoxy-biphenyl-3-ylmethyl)-[1-(1-methyl-2,3-dihydro-1H-indol-4-yl)-ethyl]-amineHCID 2239154955%

Reaktionsschritte

The title compound was prepared by the same procedure for (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-quinolin-4-yl-ethyl)-amine from 1-(1-Methyl-2,3-dihydro-1H-indol-4-yl)-ethylamine (528 mg, 3.0 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (242 mg, 1.0 mmol) and sodium cyanoborohydride (1.0 g, 16 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 55% yield (221 mg, 5.5 mmol).

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07196102B2
Quelldatensatzuspto-grants-2007_03
ORD IDord-ee4f5d0fe81d446299a0c40ff00d171c
Quellennotizuspto-grants-2007_03