Ammonia → 2-(Methylthio)pyrimidin-4-amine

HRID 460440

Reaktionsgleichung

Reaktionsgleichung von HRID 460440
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[NH3:10]>CO>[CH3:9][S:8][C:4]1[N:3]=[C:2]([NH2:10])[CH:7]=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 971134-Chloro-2-methylthiopyrimidine

Produkt 1

HCID 2592252-(Methylthio)pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

Aufarbeitung

  1. temperaturecooled
  2. concentrationconcentrated
  3. additiontreated with water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. customThe concentrate was triturated with ethyl ether
  9. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-d0f51b1d18cf40e7b1cd4b0b3fd62358
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196200B2

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