Ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoate → 10-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid

HRID 460474Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 460474
C[O:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:22]C=C)[CH2:6][C:5]=2[CH:4]=1.[F:25][C:26]([F:49])([C:45]([F:48])([F:47])[F:46])[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH:32]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH:43]=[CH2:44])[C:33]([O:35]CC)=[O:34]>>[OH:2][C:3]1[CH:20]=[CH:19][C:18]2[C@@H:17]3[C@H:8]([C@H:9]4[C@@:13]([CH2:15][CH2:16]3)([CH3:14])[C@@H:12]([OH:21])[CH2:11][CH2:10]4)[C@H:7]([CH2:22][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40][CH2:39][CH2:38][CH:32]([CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][C:26]([F:25])([F:49])[C:45]([F:46])([F:47])[F:48])[C:33]([OH:35])=[O:34])[CH2:6][C:5]=2[CH:4]=1

Komponenten

3

Edukt 2

HCID 22718078Ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoateHCID 694148073-Methoxy-7alpha-(2-propenyl)estra-1,3,5(10)-trien-17beta-ol

Produkt 1

HCID 8658853010-[3,17beta-Dihydroxyestra-1,3,5(10)-trien-7alpha-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid

Versuchsvorschrift

Starting with the 3-methoxy-7α-(2-propenyl)estra-1,3,5(10)-trien-17β-ol prepared in Example 13 and ethyl 2-(6,6,7,7,7-pentafluoroheptyl)-8-nonenoate prepared separately, the same procedure as shown in Example 13 was repeated to give 10-[3,17β-dihydroxyestra-1,3,5(10)-trien-7α-yl]-2-(6,6,7,7,7-pentafluoroheptyl)decanoic acid.

Aufarbeitung

  1. customprepared separately

Quellen und Nachweise

ORD-Eintrag
ord-a3d7e40c76434b51860df903da69928a
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196081B2

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