Hydrochloric Acid → 2'-Chloro-4'-nitrovaleranilide

HRID 461016

Reaktionsgleichung

Reaktionsgleichung von HRID 461016
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[Cl:8][C:9]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:10]=1[NH2:11].Cl>N1C=CC=CC=1>[Cl:8][C:9]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:10]=1[NH:11][C:1](=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 84922-Chloro-4-nitroanilineHCID 61186Valeryl chloride

Produkt 1

HCID 36282822'-Chloro-4'-nitrovaleranilide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Valeryl chloride (12.06 g., 0.10 mole) is added dropwise to a cooled stirred solution of 2-chloro-4-nitroaniline (17.26 g., 0.10 mole) in pyridine (100 ml.). The mixture is warmed to ambient temperature, then heated (80°-100° C.) for 24 hours. The cooled solution is poured into cold 1 N hydrochloric acid (500 ml.) with stirring. The precipitated solid is collected, washed well with water and dried, 25.1 g., m.p. 80°-95° C. Recrystallization from cyclohexane yeilds mater al (19.75 g.) of m.p. 95°-97° C.

Aufarbeitung

  1. temperatureheated (80°-100° C.) for 24 hours
  2. customThe precipitated solid is collected
  3. washwashed well with water
  4. customdried
  5. customRecrystallization from cyclohexane yeilds mater al (19.75 g.) of m.p. 95°-97° C.

Quellen und Nachweise

ORD-Eintrag
ord-d4f1e078f43441bc9440b3fbf4ae946d
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061763

Verknüpfte Notizen

Wird geladen…