N,N'-Dicyclopropylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461133Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461133
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:19][C:20]([NH:22][CH:23]2[CH2:25][CH2:24]2)=[S:21])[CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:21][C:20](=[N:19][CH:16]3[CH2:18][CH2:17]3)[N:22]2[CH:23]2[CH2:25][CH2:24]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Komponenten

3

Edukt 2

HCID 17750075N,N'-DicyclopropylthioureaHCID 213167492,4'-Dichloro-3'-sulfamoylacetophenone

Produkt 1

HCID 227605674-(4-Chloro-3-sulfamoylphenyl)-3-cyclopropyl-2-cyclopropylimino-1,3-thiazolidine-4-ol-hydrochloride

Versuchsvorschrift

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 3.1 g of 1,3-dicyclopropylthiourea were reacted according to the prescription given in Example 12 and the colorless crystalline precipitate of the end product was filtered off.

Aufarbeitung

  1. filtrationthe colorless crystalline precipitate of the end product was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-3126803682484742bbee70a79c7d8345
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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