Dicyclohexylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461134Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461134
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:22][C:23]([NH:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:24][C:23](=[N:22][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[N:25]2[CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

Komponenten

3

Edukt 2

HCID 727200DicyclohexylthioureaHCID 21316749HCID 21316749, Verbindung

Produkt 1

HCID 227605234-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

Versuchsvorschrift

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 4.8 g of 1,3-dicyclohexylthiourea were reacted according to the prescription made in Example 12, the end product was precipitated with 200 ml of diethyl ether and the oil was crystallized after decanting the solvent with diethyl ether. Colorless, crystalline solid body: melting point: 177° C (from acrylonitrile).

Aufarbeitung

  1. customthe end product was precipitated with 200 ml of diethyl ether
  2. customthe oil was crystallized
  3. customafter decanting the solvent with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-0cba33b3992a44f6a9575dbd8486e604
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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