Hydrochloric Acid → 4-Bromo-3-sulfamoylbenzoyl chloride

HRID 461150Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461150
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12].[ClH:15]>S(Cl)(Cl)=O.O1CCOCC1>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:15])=[O:7])=[CH:4][C:3]=1[S:11](=[O:14])(=[O:13])[NH2:12]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 5542164-Bromo-3-sulfamoylbenzoic acid

Produkt 1

HCID 213166124-Bromo-3-sulfamoylbenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24386Thionyl ChlorideLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

10 g of 4-bromo-3-sulfamoylbenzoic acid were heated under reflux in a mixture of 80 ml of thionyl chloride and 50 ml of dioxane until HCl had completely developped. Then, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether were added and the crystals were filtered off. Melting point: 138° C (decomposition).

Aufarbeitung

  1. concentrationThen, the reaction mixture was concentrated under reduced pressure to 40 ml, 200 ml of petroleum ether
  2. additionwere added
  3. filtrationthe crystals were filtered off

Quellen und Nachweise

ORD-Eintrag
ord-22347022073d468bbc2ecf5c668e254f
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061761

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