Methylamine → HCID 178484998, Verbindung

HRID 461530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461530
[CH3:1][NH2:2].[C:3]([NH:5][C:6](=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])SC)#[N:4]>C(O)C>[C:3]([NH:5][C:6]([NH:2][CH3:1])=[N:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[N:15]=[CH:16][NH:17][C:18]=1[CH3:19])#[N:4]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 1036301-Cyano-2-methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)isothiourea

Produkt 1

HCID 178484998HCID 178484998, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A solution of methylamine in ethanol (33%, 75 ml.) was added to a solution of N-cyano-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-S-methylisothiourea (10.1 g.) in ethanol (30 ml). The reaction mixture was set aside at room temperature for 2.5 hours. Following concentration under reduced pressure, the residue was recrystallized twice from isopropyl alcohol/petroleum ether, affording N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)-ethyl]guanidine, m.p. 141°-143° C.

Aufarbeitung

  1. concentrationconcentration under reduced pressure
  2. customthe residue was recrystallized twice from isopropyl alcohol/petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-5e70d313cbfe4f26b46e53cdadf4cbd3
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04063023

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