Methanesulfonic Acid → 6,8-difluoro-N-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-amine

HRID 461561Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 461561
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[F:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[NH:19]N.CS(O)(=O)=O>C(O)C>[CH3:1][NH:2][CH:3]1[CH2:8][C:7]2[C:14]3[C:13](=[C:12]([F:11])[CH:17]=[C:16]([F:18])[CH:15]=3)[NH:19][C:6]=2[CH2:5][CH2:4]1

Komponenten

5

Edukt 3

HCID 6395Methanesulfonic AcidHCID 27333012,4-Difluorophenylhydrazine hydrochlorideHCID 207606324-(Methylamino)cyclohexanone

Produkt 1

HCID 123618236,8-difluoro-N-methyl-2,3,4,9-tetrahydro-1H-carbazol-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 3.5 g. of 4-methylaminocyclohexanone, 5.1 g. of 2,4-difluorophenylhydrazine hydrochloride, and 4 g. of methanesulfonic acid in 50 ml. of absolute ethyl alcohol was heated under reflux for four hours, cooled, and filtered. The resulting solids were washed with isopropanol and treated in chloroform with 10% potassium hydroxide solution. The chloroform extract was evaporated to dryness to give 3-(methylamino)-6,8-difluoro-1,2,3,4-tetrahydrocarbazole, m.p. 135°-138° C., which was converted to the hydrochloride salt, m.p. > 280° C.

Aufarbeitung

  1. temperatureunder reflux for four hours
  2. temperaturecooled
  3. filtrationfiltered
  4. washThe resulting solids were washed with isopropanol
  5. additiontreated in chloroform with 10% potassium hydroxide solution
  6. extractionThe chloroform extract
  7. customwas evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-25d66e9a67b542cc8d7ea153b9d8a914
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04062864

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