Methylhydrazine → 5-Bromo-2-propyl-1,3-diethylisoindole

HRID 461695

Reaktionsgleichung

C(C1C=CC=CC=1CCC)CC.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][CH3:22])=[C:16]([CH2:23][CH2:24][CH3:25])[CH:15]=1.CNN.[CH2:29]([NH:32]N)[CH2:30][CH3:31].C1(NN)CC1>>[Br:13][C:14]1[CH:19]=[CH:18][C:17]2[C:16](=[C:23]([CH2:24][CH3:25])[N:32]([CH2:29][CH2:30][CH3:31])[C:20]=2[CH2:21][CH3:22])[CH:15]=1

Komponenten

Edukt 5

HCID 6061Methylhydrazine

HCID 42007Hydrazine, propyl-

HCID 1861511,2-Dipropylbenzene

HCID 19594968Cyclopropylhydrazine

HCID 213921214-Bromo-1,2-dipropylbenzene

Produkt 1

HCID 213921445-Bromo-2-propyl-1,3-diethylisoindole

Versuchsvorschrift

Following the procedure of Example 3, Step A, except that the o-dipropylbenzene of Example 3 is replaced by an equivalent amount of: 4-chloro-; 4-iodo-; and 4-bromo-1,2-dipropylbenzene and the methylhydrazine is replaced by an equivalent amount of propylhydrazine; cyclopropylhydrazine; and γ-THP-oxy-propylhydrazine, there is obtained 5-chloro, 5-iodo, and 5-bromo-2-propyl-1,3-diethylisoindole; 5-chloro-; 5-iodo-; and 5-bromo-2-cyclopropyl-1,3-diethylisoindole; and 5-chloro-; 5-iodo-; and 5-bromo-2-γ-THP-oxy-propyl-1,3-diethylisoindole, respectively; wherein THP represents tetrahydropyranyloxy.

Quellen und Nachweise

ORD-Eintrag: ord-877e129cfda0459e98ea2a4495e18143
Quelldatensatz: uspto-grants-1977_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04064139

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