Ethyl 3-furoate → N-{2-[2-(1-Methylpiperidin-2-yl)ethyl]phenyl}furan-3-carboxamide

HRID 461913

Reaktionsgleichung

Reaktionsgleichung von HRID 461913
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8]CC)=O)=[CH:2]1.[NH2:11][C:12]1[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=1[CH2:14][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1[CH3:22]>>[CH3:22][N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]1[CH2:15][CH2:14][C:13]1[CH:23]=[CH:24][CH:25]=[CH:26][C:12]=1[NH:11][C:6]([C:3]1[CH:4]=[CH:5][O:1][CH:2]=1)=[O:8]

Komponenten

3

Edukt 2

HCID 69201Ethyl 3-furoateHCID 110852822-(2-Aminophenethyl)-1-methylpiperidine

Produkt 1

HCID 20559948N-{2-[2-(1-Methylpiperidin-2-yl)ethyl]phenyl}furan-3-carboxamide

Versuchsvorschrift

Reaction of ethyl furan-3-carboxylate prepared by the method of Boyd et al, Synthesis, 545, (Oct. 1971) with 2-(2-aminophenethyl)-1-methylpiperidine according to the procedure of Example 115 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]-3-furancarboxanilide, m.p. 114.5°-115.5° C (corr.), from isopropyl ether and then ethyl acetate.

Quellen und Nachweise

ORD-Eintrag
ord-eb113b11603b47ca95fa7093ff3a8dc0
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04064254

Verknüpfte Notizen

Wird geladen…