Thionyl Chloride → HCID 21392665, Verbindung

HRID 461987

Reaktionsgleichung

Reaktionsgleichung von HRID 461987
[CH:1]12[CH:7]([CH2:8][C:9]([OH:11])=O)[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.S(Cl)([Cl:14])=O>>[CH:1]12[CH:7]([CH2:8][C:9]([Cl:14])=[O:11])[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 21392682(Bicyclo[2.2.1]heptan-7-yl)acetic acid

Produkt 1

HCID 21392665HCID 21392665, Verbindung

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

0.0455 Mole of bicyclo[2.2.1]hept-7-yl acetic acid is mixed with 20 ml. of thionyl chloride at room temperature and allowed to stand for 2 hours. The mixture is then warmed to 50° C and maintained at this temperature for another 2 hours. Excess thionyl chloride is then removed by distillation, under reduced pressure, affording a crude bicyclo[2.2.1]hept-7-yl acetyl chloride residue which is then dissolved in 50 ml. of ethyl ether and added dropwise to a concentrated aqueous ammonia solution (20 ml. of 58% wt. ammonia) at 0° C with rapid stirring. 200 Ml. of ethyl acetate is then added and the resulting mixture stirred. The organic layer is then decanted off and washed twice with water, dried over anhydrous magnesium sulfate and filtered. The filtrate is evaporated to dryness, under vacuum, affording bicyclo[2.2.1]hept-7-yl acetamide.

Aufarbeitung

  1. customat room temperature
  2. temperaturemaintained at this temperature for another 2 hours
  3. customExcess thionyl chloride is then removed by distillation, under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2acbc3974f8b48fc952c6d46d4258a94
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04064258

Verknüpfte Notizen

Wird geladen…