2-Pyridone → 3-(3-Bromophenyl)-1-methyl-5-phenyl-4-piperidinone

HRID 462014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 462014
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[C:13](=[O:14])[C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:11][N:10]([CH3:21])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC1=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>CC(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13](=[O:14])[CH:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:11][N:10]([CH3:21])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 88712-PyridoneHCID 128792753-(3-Bromophenyl)-1-methyl-5-phenylpyridin-4(1H)-oneHCID 21226445Aluminium lithium hydride

Produkt 1

HCID 203170063-(3-Bromophenyl)-1-methyl-5-phenyl-4-piperidinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A 10 g. portion of 3-(3-bromophenyl)-1-methyl-5-phenyl-4(1H)-pyridinone was made from 22 g. of the corresponding 2-propanone as described in Examples 1-3. The pyridinone was reduced with 2 g. of lithium aluminum hydride as described in the examples above, and the reaction mixture was chromatographed as described above with benzene-ethyl acetate mixtures. The combined yield of the compounds of Examples 13 and 13a was 4 g., molecular weight 341 by mass spectroscopy. The yield of the compound of Example 14 was 0.5 g., molecular weight by mass spectroscopy 343.

Aufarbeitung

  1. customwas chromatographed

Quellen und Nachweise

ORD-Eintrag
ord-fb5800782b87443bba759868cf840f5b
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065290

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