Ethanolamine → 2-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 462223

Reaktionsgleichung

Reaktionsgleichung von HRID 462223
Cl[N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[CH2:16]([CH2:18][NH2:19])[OH:17]>O1CCOCC1>[OH:17][CH2:16][CH2:18][NH:19][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 213908012-(2-Chloro-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Produkt 1

HCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A mixture consisting of 4.9 gm., 0.02 mole, of 2-(2-chloro- 5-thiadiazoly)-1-methyl-5-nitroimidazole, 3.0 gm., 0.05 mole, of ethanolamine, and 50 ml. of p-dioxane is stirred at room temperature for twenty-four hours. The precipitate is collected, washed with aqueous sodium bicarbonate solution, dried and recrystallized from methanol to give the pure compound melting at 208°-209° C. Working up the mother liquors gives additional material, the total yield being 3.4 gm.

Aufarbeitung

  1. customThe precipitate is collected
  2. washwashed with aqueous sodium bicarbonate solution
  3. customdried
  4. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-94c382ef593f420b8f9d79b441cf0819
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065567

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