2,3-Dibromopropanenitrile → 2-Cyano-1-(3-fluorobenzyloxy)-aziridine
Reaktionsgleichung
Br[CH:2]([CH2:5]Br)[C:3]#[N:4].[F:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[CH2:11][O:12][NH2:13]>>[C:3]([CH:2]1[CH2:5][N:13]1[O:12][CH2:11][C:10]1[CH:14]=[CH:15][CH:16]=[C:8]([F:7])[CH:9]=1)#[N:4]Komponenten
3
Versuchsvorschrift
Analogously to Example 4, by the reaction of 2,3-dibromopropionitrile with O-(3-fluorobenzyl)-hydroxylamine, there is obtained 2-cyano-1-(3-fluorobenzyloxy)-aziridine (see Example 4d). The two invertomers can be separated by column chromatographic separation on silica gel (elution agent diethyl ether/ligroin 1/1 v/v) to give:
Quellen und Nachweise
- ORD-Eintrag
- ord-2b58c889ac8e4392b9a8ab21eb014638
- Quelldatensatz
- uspto-grants-1985_05
- Patentnummer
- US04517183
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