Iodine → 2,3-Dichloro-5-iodopyridine
Reaktionsgleichung
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Li])=[CH:4][N:3]=1.[I:10]I>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([I:10])=[CH:4][N:3]=1Komponenten
3
Versuchsvorschrift
Briefly, in accordance with the present invention, 2,3-dichloro-5-iodopyridine is prepared by lithiating 5-bromo-2,3-dichloropyridine at a reduced temperature to form 2,3-dichloro-5-lithiopyridine. The 2,3-dichloro-5-lithiopyridine is then reacted with I2 at a reduced temperature to form 2,3-dichloro-5-iodopyridine. The resulting product is then extracted and recovered. 2,3-Dichloro-5-iodopyridine is in the form of a white solid and has a melting point of from 56.5° C. to 57.5° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-bec383ef62d84f5d9dae01d4b115ad24
- Quelldatensatz
- uspto-grants-1985_05
- Patentnummer
- US04517368
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