Diketene → 2-(N-Acetoacetyl-piperazino)-8-methylthio-4-thiomorpholinopyrimido-[5,4-d]-pyrimidine

HRID 462944

Reaktionsgleichung

Reaktionsgleichung von HRID 462944
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.[CH3:7][S:8][C:9]1[C:14]2[N:15]=[C:16]([N:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1>ClC1N=C(N2CCS(=O)CC2)C2N=CN=C(Cl)C=2N=1>[C:4]([N:28]1[CH2:29][CH2:30][N:25]([C:16]2[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22][CH2:21][CH2:20]3)[C:13]3[N:12]=[CH:11][N:10]=[C:9]([S:8][CH3:7])[C:14]=3[N:15]=2)[CH2:26][CH2:27]1)(=[O:5])[CH2:3][C:2]([CH3:1])=[O:6]

Komponenten

4

Edukt 2

HCID 12661DiketeneHCID 201502198-Methylthio-2-piperazino-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine

Produkt 1

HCID 201501812-(N-Acetoacetyl-piperazino)-8-methylthio-4-thiomorpholinopyrimido-[5,4-d]-pyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 128169922,8-Dichloro-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidineLösungsmittel

Versuchsvorschrift

1.6 gm (0.02 mol) of diketene were slowly poured, while stirring, into a solution of 3.6 gm (0.01 mol) of 8-methylthio-2-piperazino-4-thiomorpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 177°-179° C.) in 50 ml of dioxane. After stirring for 30 minutes more, the solvent was evaporated in vacuo, and the residue was taken up in about 100 ml of water. The precipitated reaction product was suction-filtered off, washed with water and dried.

Aufarbeitung

  1. customthe solvent was evaporated in vacuo
  2. customThe precipitated reaction product
  3. filtrationwas suction-filtered off
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-806586c5845f4dc48bdc482c1ab4064c
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04518596

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