Benzoic acid, 3-methoxy-2-nitro-, methyl ester → Methyl 2-amino-3-methoxybenzoate

HRID 463065

Reaktionsgleichung

Reaktionsgleichung von HRID 463065
[CH3:1][O:2][C:3]1[C:4]([N+:13]([O-])=O)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7]>C1(C)C=CC=CC=1.[Pt]>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:5]([C:6]([O:8][CH3:9])=[O:7])[C:4]=1[NH2:13]

Komponenten

4

Edukt 1

HCID 79195Benzoic acid, 3-methoxy-2-nitro-, methyl ester

Produkt 1

HCID 602320Methyl 2-amino-3-methoxybenzoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 1140TolueneLösungsmittel

Versuchsvorschrift

One hundred thirty-three grams (0.63 mol) of methyl 3-methoxy-2-nitro-benzoate are dissolved in 1000 ml of toluene and hydrogenated in an autoclave at ambient temperature and under a hydrogen pressure of 5 bar in the presence of platinum over a period of two hours. The catalyst is removed by filtration, the residue is dried with sodium sulfate, and the toluene is distilled off in vacuo. Oil, RF value: 0.8 [silica gel plate; chloroform/acetone (9:1)],

Aufarbeitung

  1. customhydrogenated in an autoclave at ambient temperature and under a hydrogen
  2. customof two hours
  3. customThe catalyst is removed by filtration
  4. dry with materialthe residue is dried with sodium sulfate
  5. distillationthe toluene is distilled off in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b6f69015d892488a930568c8d1363b2b
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04518597

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