Benzeneacetamide,a-hydroxy-n-(2-phenylethyl)- → HCID 20283355, Verbindung

HRID 463447

Reaktionsgleichung

Reaktionsgleichung von HRID 463447
[CH2:1]([NH:9][C:10](=[O:19])[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[OH:12])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:20]([C:23]1[CH:33]=[CH:32][CH:31]=[CH:30][C:24]=1[CH:25]([OH:29])[C:26](Cl)=[O:27])(=[O:22])[CH3:21]>N1C=CC=CC=1>[CH2:1]([NH:9][C:10](=[O:19])[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[O:12][C:26](=[O:27])[CH:25]([C:24]1[CH:30]=[CH:31][CH:32]=[CH:33][C:23]=1[C:20](=[O:22])[CH3:21])[OH:29])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Komponenten

4

Edukt 2

HCID 9992529Benzeneacetamide,a-hydroxy-n-(2-phenylethyl)-HCID 21976940(2-Acetylphenyl)(hydroxy)acetyl chloride

Produkt 1

HCID 20283355HCID 20283355, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

N-phenethyl mandelic amide 51 g is dissolved in 150 ml of pyridine, and o-acetylmandelic acid chloride 60 ml is added with stirring. Exothermic acylation takes place immediately and the stirring is continued for 5 hours. The reaction mixture is mixed with 1 liter of cold 0.2N HCL. The sticky solid thus formed is extracted with 300 ml of chloroform, washed with 400 ml of 5% sodium bicarbonate and is dried over anhydrous sodium sulfate. On evaporation of chloroform a syrupy product 98 g is obtained.

Aufarbeitung

  1. additionThe reaction mixture is mixed with 1 liter of cold 0.2N HCL
  2. customThe sticky solid thus formed
  3. extractionis extracted with 300 ml of chloroform
  4. washwashed with 400 ml of 5% sodium bicarbonate
  5. dry with materialis dried over anhydrous sodium sulfate
  6. customOn evaporation of chloroform a syrupy product 98 g
  7. customis obtained

Quellen und Nachweise

ORD-Eintrag
ord-3c3f149fbf154f32972b6cbad0ddd15b
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04518789

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