Bromo(phenyl)acetic acid → HCID 13457847, Verbindung

HRID 463541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 463541
[K].[SH:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=1.Br[CH:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:15]([OH:17])=[O:16]>CC(C)=O>[CH3:8][N:7]1[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=[C:3]1[S:2][CH:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:15]([OH:17])=[O:16]

Komponenten

5

Edukt 3

HCID 97919Bromo(phenyl)acetic acidHCID 5462222PotassiumHCID 178481665HCID 178481665, Verbindung

Produkt 1

HCID 13457847HCID 13457847, VerbindungAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

An acetone solution of 6.5 g (0.032M) of the potassium salt of 2-mercapto-1-methyl-benzimidazole and 9.7 g (0.045M) of α-bromophenylacetic acid is stirred at room temperature overnight. The solid which is collected is washed with water and the filtrate is concentrated to remove the solvent. The combined materials are recrystallized from acetonitrile. The recrystallized material weighs 8.3 g (87% yield) and melts at 157°-9° C.

Aufarbeitung

  1. customThe solid which is collected
  2. washis washed with water
  3. concentrationthe filtrate is concentrated
  4. customto remove the solvent
  5. customThe combined materials are recrystallized from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-0e720e6359ac45a1ac14bdaecc5217cc
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04520196

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