9-Methoxyacridine → HCID 178419977, Verbindung

HRID 463686Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 463686
CO[C:3]1[C:4]2[C:9]([N:10]=[C:11]3[C:16]=1[CH:15]=[CH:14][CH:13]=[CH:12]3)=[CH:8][CH:7]=[CH:6][CH:5]=2.Br.[NH:18]([C:20]1[S:21][CH2:22][CH2:23][N:24]=1)[NH2:19]>C(O)C>[S:21]1[CH2:22][CH2:23][NH:24][C:20]1=[N:18][N:19]=[C:3]1[C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=2[NH:10][C:11]2[C:16]1=[CH:15][CH:14]=[CH:13][CH:12]=2

Komponenten

4

Edukt 2

HCID 993839-MethoxyacridineHCID 27743032-Thiazolidinone, hydrazone, hydrobromide

Produkt 1

HCID 178419977HCID 178419977, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

2.09 g of 9-methoxyacridine are dissolved in 50 ml of dry ethanol, treated with a solution of 1.98 g of 2-hydrazino-2-thiazoline hydrobromide in 50 ml of dry ethanol, heated to boiling under reflux for 1 hour and the solvent is removed in vacuo. The residue is treated with aqueous ammonia (1:5) and extracted with ethyl acetate. After drying the extract over sodium sulfate and evaporation, the material obtained is crystallized by the addition of pentane. There is obtained 9-acridanone (2-thiazolidinylidene)hydrazone of melting point 214°-215° (decomposition).

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux for 1 hour
  3. customthe solvent is removed in vacuo
  4. additionThe residue is treated with aqueous ammonia (1:5)
  5. extractionextracted with ethyl acetate
  6. customAfter drying the
  7. extractionextract over sodium sulfate and evaporation
  8. customthe material obtained
  9. customis crystallized by the addition of pentane

Quellen und Nachweise

ORD-Eintrag
ord-9a42fb80520f46c7866f1da388e48008
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04544659

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