Chloroacetaldehyde → 10-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

HRID 463691Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 463691
[CH3:1][N:2]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[N:16][NH:17][C:18]([NH2:20])=[S:19])[C:8]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]1=2.[Cl:21][CH2:22][CH:23]=O>CO>[ClH:21].[S:19]1[CH:23]=[CH:22][N:20]=[C:18]1[NH:17][N:16]=[C:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[N:2]([CH3:1])[C:3]2[C:8]1=[CH:7][CH:6]=[CH:5][CH:4]=2

Komponenten

4

Edukt 2

HCID 33ChloroacetaldehydeHCID 5201653HCID 5201653, Verbindung

Produkt 1

HCID 2483272110-Methyl-9-[2-(1,3-thiazol-2-yl)hydrazinylidene]-9,10-dihydroacridine--hydrogen chloride (1/1)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

1.9 g of 10-methyl-9acridanone thiosemicarbazone are suspended in 100 ml of methanol and stirred at 50° for 6 hours with 1.73 ml of chloroacetaldehyde (50percent aqueous solution). The mixture is concentrated, the crystalline product is filtered and washed successively with ethanol, water, ethanol and ether. There is obtained 10-methyl-9-acridanone (2-thiazolyl)hydrazone hydrochloride of melting point 224°-225° (decomposition).

Aufarbeitung

  1. concentrationThe mixture is concentrated
  2. filtrationthe crystalline product is filtered
  3. washwashed successively with ethanol, water, ethanol and ether

Quellen und Nachweise

ORD-Eintrag
ord-aa47c8a0a0c044e287f215bea23de30f
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04544659

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