(Trimethylsilyl)imidazole → HCID 178424778, Verbindung

HRID 463747

Reaktionsgleichung

Reaktionsgleichung von HRID 463747
C[Si](C)(C)[N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1.Cl[CH:11]([C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:20])[CH3:12]>C(Cl)(Cl)Cl.[Ti](Cl)(Cl)(Cl)Cl>[CH3:12][CH:11]([C:7]1[N:3]=[CH:4][NH:5][CH:6]=1)[C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:20]

Komponenten

5

Edukt 2

HCID 28925(Trimethylsilyl)imidazoleHCID 15637774HCID 15637774, Verbindung

Produkt 1

HCID 178424778HCID 178424778, VerbindungAusbeute 33 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 24193Titanium TetrachlorideKatalysatorHCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a mixture of N-(trimethylsilyl)imidazole (1.4 g) and titanium tetrachloride (1.6 ml) in dry chloroform (20 ml) a solution of 1-chloro-1-(2,6-dimethylphenyl)ethane (1.7 g) in dry chloroform (10 ml) was added. After stirring for 5 h at room temperature the product mixture was poured onto water, washed with ether and neutralized with sodium hydrogen carbonate. Filtration and extraction with methylene chloride gave 4-[(α-methyl)-2,6-dimethylbenzyl]imidazole, yield 33%.

Aufarbeitung

  1. additionwas added
  2. additionwas poured onto water
  3. washwashed with ether and neutralized with sodium hydrogen carbonate
  4. filtrationFiltration and extraction with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-5182a32d8ac74ff886180262203ed2f1
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04544664

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