Thionyl Chloride → 2-Methyl-3-hydroxy-4-chloromethyl-5-vinylpyridine hydrochloride
Reaktionsgleichung
[ClH:1].[CH3:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:10]O)[C:6]([CH:12]=[CH2:13])=[CH:5][N:4]=1.S(Cl)([Cl:16])=O>O1CCCC1>[ClH:16].[CH3:2][C:3]1[C:8]([OH:9])=[C:7]([CH2:10][Cl:1])[C:6]([CH:12]=[CH2:13])=[CH:5][N:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 1.65 g. of 2-methyl-3-hydroxy-4-hydroxymethyl-5-vinylpyridine hydrochloride, 1 ml. of thionyl chloride and 20 ml. of tetrahydrofuran is refluxed 6 hours. After cooling, the precipitate is collected on a filter, washed with ether and dried to give 2-methyl-3-hydroxy-4-chloromethyl-5-vinyl pyridine hydrochloride.
Aufarbeitung
- additionA mixture of 1.65 g
- temperatureAfter cooling
- customthe precipitate is collected on a filter
- washwashed with ether
- customdried
Quellen und Nachweise
- ORD-Eintrag
- ord-c07ab77d4c974903b66a50c912ba3161
- Quelldatensatz
- uspto-grants-1985_10
- Patentnummer
- US04546106
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