Hydrochloric Acid → 3-Chloro-5-(trifluoromethyl)pyridin-2-ol

HRID 464130

Reaktionsgleichung

Reaktionsgleichung von HRID 464130
Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([C:9]([F:12])([F:11])[F:10])=[CH:4][N:3]=1.[OH-:13].[K+].Cl>C(O)(C)(C)C>[Cl:8][C:7]1[C:2](=[O:13])[NH:3][CH:4]=[C:5]([C:9]([F:12])([F:11])[F:10])[CH:6]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Produkt 1

HCID 7254363-Chloro-5-(trifluoromethyl)pyridin-2-olAusbeute 75,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel

Versuchsvorschrift

4.5 g of 2,3-dichloro-5-trifluoromethylpyridine was added to a solution of 2.7 g of potassium hydroxide dissolved in 40 ml of t-butanol, and the mixture was reacted at the reflux temperature for one hour while stirring. After completion of the reaction, the reaction product was allowed to cool and made acidic with concentrated hydrochloric acid. The contents were concentrated under reduced pressure to obtain a solid which was then purified to obtain 3.1 g of the titled compound having a melting point of 165° to 166° C.

Aufarbeitung

  1. customthe mixture was reacted at the reflux temperature for one hour
  2. customAfter completion of the reaction
  3. temperatureto cool
  4. concentrationThe contents were concentrated under reduced pressure
  5. customto obtain a solid which
  6. customwas then purified

Quellen und Nachweise

ORD-Eintrag
ord-3a6e9ed31a844b1ba572167156dce05f
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04546191

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