Ethyl orthopropionate → 4,8-Dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline

HRID 464297Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464297
[Cl:1][C:2]1[C:11]([NH:12][NH2:13])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:14])[CH:8]=2)[N:3]=1.[C:15](OCC)(OCC)(OCC)[CH2:16][CH3:17]>>[Cl:1][C:2]1[C:11]2[N:10]([C:15]([CH2:16][CH3:17])=[N:13][N:12]=2)[C:9]2[C:4]([N:3]=1)=[CH:5][CH:6]=[C:7]([Cl:14])[CH:8]=2

Komponenten

3

Edukt 2

HCID 66995Ethyl orthopropionateHCID 14733462,6-Dichloro-3-hydrazinylquinoxaline

Produkt 1

HCID 133857214,8-Dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxalineAusbeute 62 %

Versuchsvorschrift

2,6-Dichloro-3-hydrazinoquinoxaline (1.0 g., 0.0044 mole), the product of Preparation L(a), was refluxed with 15 ml. of triethyl orthopropionate for 4 hours and cooled to room temperature. The precipitate was recovered by filtration, washed with cyclohexane and air dried to afford 730 mg. (62% yield) of 4,8-dichloro-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. >250° C. Mass spectrum: m/e, 266 (P); m/e, 268 (P.+2).

Aufarbeitung

  1. temperaturewas refluxed with 15 ml
  2. filtrationThe precipitate was recovered by filtration
  3. washwashed with cyclohexane and air
  4. customdried
  5. customto afford 730 mg

Quellen und Nachweise

ORD-Eintrag
ord-37d664edb9e64e5db26d68c113b48445
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04547501

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