HCID 12951525, Verbindung → HCID 53742088, Verbindung

HRID 464338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464338
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[CH3:6].CS[C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1>N1C=CC=CC=1>[CH3:6][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:15]1[NH:20][C:19](=[O:21])[C:18]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:17][N:16]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1

Komponenten

4

Edukt 2

HCID 12951525HCID 12951525, VerbindungHCID 20262876N-(3-Aminopropyl)-N-methylpyridin-2-amine

Produkt 1

HCID 53742088HCID 53742088, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-[N-(3-aminopropyl)-N-methylamino]pyridine (1.98 g) and 2-methylthio-5-(4-hydroxybenzyl)pyrimid-4-one (2.48 g) were heated together under reflux in pyridine (5 ml) for 24 hr. After stripping, the residue was triturated with water (pH adjusted to 7.0 with 2N hydrochloric acid). Recrystallisation from ethanol/water and again from methanol gave 2-[3-(N-methyl-N-pyrid-2-ylamino)propyl-amino]-5-(4-hydroxybenzyl) pyrimid-4-one, 2.4 g (66%) mp 109°-11° C. (analytical sample from methanol).

Aufarbeitung

  1. customthe residue was triturated with water (
  2. customRecrystallisation from ethanol/water

Quellen und Nachweise

ORD-Eintrag
ord-a7b0736573d3426482a03bd4395dc92b
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04547506

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