HCID 13622586, Verbindung → HCID 13622609, Verbindung
Reaktionsgleichung
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]([NH:21][C@@H:22]1[C:28](=[O:29])[N:27]([CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[C:26]2[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=2[O:24][CH2:23]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17])=O)(C)(C)C.C(OCC)(=O)C.[ClH:48]>>[ClH:48].[ClH:48].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C@H:15]([NH:21][C@@H:22]1[C:28](=[O:29])[N:27]([CH2:30][C:31]([OH:33])=[O:32])[C:26]2[CH:38]=[CH:39][CH:40]=[CH:41][C:25]=2[O:24][CH2:23]1)[C:16]([O:18][CH2:19][CH3:20])=[O:17]Komponenten
3
Versuchsvorschrift
In 10 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 1.1 g of tert-butyl 3(S)-[7-tert-butoxycarbonylamino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate obtained in Example 67 and the solution is allowed to stand at room temperature for 3 hours. Petroleum ether (100 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.9 g of 3(S)-[7-amino-1(S)-ethoxycarbonylheptyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid dihydrochloride as a colorless powder.
Aufarbeitung
- customthe deposited precipitate is dried under reduced pressure